Lymphocyte life and death: The caspase-8 connection
نویسندگان
چکیده
منابع مشابه
Controlling caspase activity in life and death
Every day, billions of human cells terminate their normal activities and launch intrinsic suicide pathways. Timely cell death is orchestrated by destructive functions encoded by dying cells, such as caspase proteases in the case of apoptotic or pyroptotic cell death. Caspases cleave specific intracellular substrates to kill and dismantle cells destined for elimination, and their dysregulation l...
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Apoptosis is an important physiological process which enables organisms to remove unwanted or damaged cells. A mathematical model of the extrinsic pro-apoptotic signaling pathway has been introduced by Eissing et al. (2007) and a bistable behavior with a stable death state and a stable life state of the reaction system has been established. In this paper, we consider a spatial extension of the ...
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The differentiation and senescence programs of metazoans play key roles in regulating normal development and preventing aberrant cell proliferation, such as cancer. These programs are intimately associated with both the mitotic and apoptotic pathways. Caspase-8 is an apical apoptotic initiator that has recently been appreciated to coordinate non-apoptotic roles in the cell. Most of these functi...
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ژورنال
عنوان ژورنال: Cancer Biology & Therapy
سال: 2005
ISSN: 1538-4047,1555-8576
DOI: 10.4161/cbt.4.7.1910